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Cocoa Flavanols Boost Brain Oxygenation and Cognition in Healthy Adults. November 24, 2020

  • Writer: Patricia Faust
    Patricia Faust
  • Dec 3, 2020
  • 3 min read

Summary: Those exposed to cocoa flavanols performed better at cognitive tests and showed increases in brain oxygenation.

Source: University of Illinois


The brains of healthy adults recovered faster from a mild vascular challenge and performed better on complex tests if the participants consumed cocoa flavanols beforehand, researchers report in the journal Scientific Reports. In the study, 14 of 18 participants saw these improvements after ingesting the flavanols.


Previous studies have shown that eating foods rich in flavanols can benefit vascular function, but this is the first to find a positive effect on brain vascular function and cognitive performance in young healthy adults, said Catarina Rendeiro, a researcher and lecturer in nutritional sciences at the University of Birmingham who led the research with University of Illinois at Urbana-Champaign psychology professors Monica Fabiani and Gabriele Gratton.


“Flavanols are small molecules found in many fruits and vegetables, and cocoa, too,” Rendeiro said. “They give fruits and vegetables their bright colors, and they are known to benefit vascular function. We wanted to know whether flavanols also benefit the brain vasculature, and whether that could have a positive impact on cognitive function.”


The team recruited adult nonsmokers with no known brain, heart, vascular or respiratory disease, reasoning that any effects seen in this population would provide robust evidence that dietary flavanols can improve brain function in healthy people.


The team tested the 18 participants before their intake of cocoa flavanols and in two separate trials, one in which the subjects received flavanol-rich cocoa and another during which they consumed processed cocoa with very low levels of flavanols. Neither the participants nor researchers knew which type of cocoa was consumed in each of the trials. This double-blind study design prevents researchers’ or participants’ expectations from affecting the results.


About two hours after consuming the cocoa, participants breathed air with 5% carbon dioxide – about 100 times the normal concentration in air. This is a standard method for challenging brain vasculature to determine how well it responds, Gratton said.


The body typically reacts by increasing blood flow to the brain, he said.

“This brings in more oxygen and also allows the brain to eliminate more carbon dioxide,” he said.


With functional near-infrared spectroscopy, a technique that uses light to capture changes in blood flow to the brain, the team measured oxygenation in the frontal cortex, a brain region that plays a key role in planning, regulating behavior and decision-making.


“This allows you to measure how well the brain defends itself from the excess carbon dioxide,” Fabiani said.


Researchers also challenged participants with complex tasks that required them to manage sometimes contradictory or competing demands.


Most of the participants had a stronger and faster brain oxygenation response after exposure to cocoa flavanols than they did at baseline or after consuming cocoa lacking flavanols, the researchers found.


“The levels of maximal oxygenation were more than three times higher in the high-flavanol cocoa versus the low-flavanol cocoa, and the oxygenation response was about one minute faster,” Rendeiro said.


After ingesting the cocoa flavanols, participants also performed better on the most challenging cognitive tests, correctly solving problems 11% faster than they did at baseline or when they consumed cocoa with reduced flavanols. There was no measurable difference in performance on the easier tasks, however.


Participants varied in their responses to cocoa flavanols, the researchers found.

“Although most people benefited from flavanol intake, there was a small group that did not,” Rendeiro said. Four of the 18 study subjects had no meaningful differences in brain oxygenation response after consuming flavanols, nor did their performance on the tests improve.


“Because these four participants already had the highest oxygenation responses at baseline, this may indicate that those who are already quite fit have little room for improvement,” Rendeiro said. “Overall, the findings suggest that the improvements in vascular activity after exposure to flavanols are connected to the improvement in cognitive function.”


Fabiani and Gratton are affiliates of the Beckman Institute for Advanced Science and Technology at the U. of I.


 
 
 

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March was an unusual month for me.  Normally I work on articles, give presentations and generally just stay tuned to what is going on in the field of aging.  This month I “learned” a lot.  Last year I learned how to write a book.  At the time I took the course I thought it would just be a natural extension of all the writing I had done over the years.  WRONG!!  The actual writing of the book was the easy part.  Putting it together into a book was difficult for me.  The course gave me step by step lessons on constructing a book.  Then editing and formatting were just as challenging.  On June 7 last year the book was published!  It was one of the most satisfying days of my writing career. 

Naturally, when you self-publish, you do not have a publisher promoting the book and getting it in the right categories for best sales on Amazon.  That was crushing because I really didn’t know to appropriately market it.  I am a brain health person!  In December of last year, I purchased a marketing program that is based on statistics.  I am technical minded and so this approach made sense to me.  The course is almost completed.  Can’t wait to see if it improves sales!

The next step I am looking at is recording an audiobook.  This is another venture I knew nothing about.  But I am already tagged on Facebook for marketing of audio book programs.  Facebook picks up everything.  Now my husband was creative director for an advertising agency and when I told him I purchased another class – he couldn’t believe it.  “This was my business.  I know how to do recordings, why didn’t you ask me?” Well, I knew he was an expert in that business, but this audiobook needs to meet all the criteria that Amazon requires for publication.  So, he can take care of the recording part of this audiobook, and I will navigate the process of meeting Amazon’s requirements.  We worked on the book together like this. 

Then I talked with some coaching experts on the viability of starting group teaching programs.  Reading The Boomer Brain book and implementing the Brain Healthy Lifestyle have two entirely different outcomes.  This lifestyle is important to maintaining high cognitive function throughout the later years of our lives.  Look for updates as to when I will roll this program out.

My last learning endeavor was attending a two-day bootcamp for Speakers.  I am really excited about what I learned there.  That is a late this year or next year project, but it is one I am really looking forward to.

 

What Is Happening in April?

The American Society on Aging is having their annual conference in Orlando Florida April 21-24.  This is the largest multidisciplinary conference on aging and the annual conference for Members of ASA.  I have attended a number of these conferences throughout the years, and it is consequential.  Keynote speakers and special events are focused on combating ageism in our society.  Although this is a professional meeting, the attendees come from all aspects of aging services.  They have their work cut out for them this year!

April is Stress Awareness Month.  We should be aware of stress every month and understand how we can break the stress cycle.  These are stressful times, and we need to protect ourselves

Here is a positive one “April is National Volunteer Month”.  When I am working with new retirees who don’t know what to do, I talk to them about volunteering. It is important to have a purpose after you leave the workforce.  There are so many nonprofits who need help in all aspects of their organizations.  It is a perfect way to give back.

Finally – It was Opening Day for the Cincinnati Reds – the oldest major league team in the nation.  Cincinnati takes that responsibility seriously.  There is always an Opening Day Parade through downtown to the Ball Park.  Huge crowds line the streets and every year there is talk of making it an official holiday.  Schools and employers look the other way when there is an empty desk.  No matter what the outcome of the game is, there is so much joy, and you can feel that energy.  I am fortunate that I get to experience that.  We all need some joy right now. 

Enjoy your April.

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